Researchers studying ageing in mice have found that a decline in chaperone-mediated autophagy (CMA), a cellular recycling process, helps “zombie cells” accumulate by weakening the immune system’s ability to clear them. Restoring CMA reduced senescent-cell buildup, inflammation and fibrosis in mice, pointing to a possible new approach to age-related diseases.
Researchers studying ageing in mice have found that a decline in chaperone-mediated autophagy (CMA), a cellular recycling process, helps “zombie cells” accumulate by weakening the immune system’s ability to clear them. Restoring CMA reduced senescent-cell buildup, inflammation and fibrosis in mice, pointing to a possible new approach to age-related diseases.
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